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claude-codescience

Babysitter mageck-crispr-analyzer

MAGeCK CRISPR screen analysis skill for gene essentiality scoring

install
source · Clone the upstream repo
git clone https://github.com/a5c-ai/babysitter
Claude Code · Install into ~/.claude/skills/
T=$(mktemp -d) && git clone --depth=1 https://github.com/a5c-ai/babysitter "$T" && mkdir -p ~/.claude/skills && cp -r "$T/library/specializations/domains/science/bioinformatics/skills/mageck-crispr-analyzer" ~/.claude/skills/a5c-ai-babysitter-mageck-crispr-analyzer && rm -rf "$T"
manifest: library/specializations/domains/science/bioinformatics/skills/mageck-crispr-analyzer/SKILL.md
tags
#crispr-analysis#gene-essentiality#screening#bioinformatics#sequence-processing
source content

MAGeCK CRISPR Analyzer Skill

Purpose

Provide MAGeCK CRISPR screen analysis for gene essentiality scoring.

Capabilities

  • Guide read counting
  • Normalization and QC
  • Gene-level analysis
  • Pathway enrichment
  • MLE model for complex designs
  • Visualization outputs

Usage Guidelines

  • Count guides accurately from sequencing data
  • Normalize counts appropriately
  • Calculate gene-level scores
  • Enrich for biological pathways
  • Use MLE for complex experimental designs
  • Generate informative visualizations

Dependencies

  • MAGeCK
  • BAGEL
  • CRISPResso2

Process Integration

  • CRISPR Screen Analysis (crispr-screen-analysis)