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Babysitter pharmgkb-annotator

PharmGKB pharmacogenomics annotation skill for drug-gene interaction assessment

install
source · Clone the upstream repo
git clone https://github.com/a5c-ai/babysitter
Claude Code · Install into ~/.claude/skills/
T=$(mktemp -d) && git clone --depth=1 https://github.com/a5c-ai/babysitter "$T" && mkdir -p ~/.claude/skills && cp -r "$T/library/specializations/domains/science/bioinformatics/skills/pharmgkb-annotator" ~/.claude/skills/a5c-ai-babysitter-pharmgkb-annotator && rm -rf "$T"
manifest: library/specializations/domains/science/bioinformatics/skills/pharmgkb-annotator/SKILL.md
tags
#pharmacogenomics#clinical-genomics#cpic#drug-response#variant-interpretation
source content

PharmGKB Annotator Skill

Purpose

Provide PharmGKB pharmacogenomics annotation for drug-gene interaction assessment.

Capabilities

  • Star allele calling (Stargazer)
  • Diplotype determination
  • CPIC guideline integration
  • Drug recommendation generation
  • Clinical annotation lookup
  • Dosing guidance extraction

Usage Guidelines

  • Call star alleles accurately
  • Determine diplotypes from genotypes
  • Apply CPIC guidelines for dosing
  • Generate actionable recommendations
  • Review clinical annotations
  • Document guideline versions

Dependencies

  • PharmGKB API
  • Stargazer
  • PharmCAT

Process Integration

  • Pharmacogenomics Analysis (pharmacogenomics-analysis)
  • Clinical Variant Interpretation (clinical-variant-interpretation)