Source: https://github.com/aipoch/medical-research-skills

Cohort Study Quality Assessment (NOS)

This skill evaluates the quality of a cohort study based on the Newcastle-Ottawa Scale (NOS). It analyzes Selection, Comparability, and Outcome categories and generates a scored report.

When to Use

• Use this skill when the request matches its documented task boundary.
• Use it when the user can provide the required inputs and expects a structured deliverable.
• Prefer this skill for repeatable, checklist-driven execution rather than open-ended brainstorming.

Key Features

• Scope-focused workflow aligned to: Evaluates the quality of cohort studies using the Newcastle-Ottawa Scale (NOS). Use when the user provides a cohort study article or text and needs a quality assessment report.
• Packaged executable path(s):

  scripts/calculate_nos_score.py

  plus 1 additional script(s).
• Reference material available in

  references/

  for task-specific guidance.
• Structured execution path designed to keep outputs consistent and reviewable.

Dependencies

See

## Prerequisites

above for related details.

• Python

  :

  3.10+

  . Repository baseline for current packaged skills.

• Third-party packages

  :

  not explicitly version-pinned in this skill package

  . Add pinned versions if this skill needs stricter environment control.

Example Usage

See

## Usage

above for related details.

cd "20260316/scientific-skills/Data Analytics/cohort-study-quality-assessment-nos"
python -m py_compile scripts/calculate_nos_score.py
python scripts/calculate_nos_score.py --help

Example run plan:

1. Confirm the user input, output path, and any required config values.
2. Edit the in-file

   CONFIG

   block or documented parameters if the script uses fixed settings.
3. Run

   python scripts/calculate_nos_score.py

   with the validated inputs.
4. Review the generated output and return the final artifact with any assumptions called out.

Implementation Details

See

## Workflow

above for related details.

• Execution model: validate the request, choose the packaged workflow, and produce a bounded deliverable.
• Input controls: confirm the source files, scope limits, output format, and acceptance criteria before running any script.
• Primary implementation surface:

  scripts/calculate_nos_score.py

  with additional helper scripts under

  scripts/

  .
• Reference guidance:

  references/

  contains supporting rules, prompts, or checklists.
• Parameters to clarify first: input path, output path, scope filters, thresholds, and any domain-specific constraints.
• Output discipline: keep results reproducible, identify assumptions explicitly, and avoid undocumented side effects.

Prerequisites

• Python 3.x
• PyPDF2 library (

  pip install PyPDF2

  )
• Access to

  references/nos_criteria.md

  for detailed evaluation criteria

Usage

Method 1: Direct Text Input

1. Input: The full text of the cohort study article (copy-pasted or provided by user).
2. Process:
   • Extract study metadata (Author, Year).
   • Evaluate the study against NOS criteria (Selection, Comparability, Outcome).
   • Calculate the total score (number of stars).
3. Output: A Markdown table summarizing the assessment for each criterion and the overall score.

Method 2: PDF File Input

1. Input: Path to a PDF file containing the cohort study.
2. Process:
   • Use

     scripts/extract_pdf.py

     to extract text from the PDF.
   • Review the extracted text for completeness.
   • Proceed with Method 1 steps.
3. Output: Same as Method 1.

Workflow

Step 1: Extract Content

If input is PDF:

cd "D:\helix\test record\\262\skills_\skills\cohort-study-quality-assessment-nos"
python scripts/extract_pdf.py "path/to/your/file.pdf"

Note: The extracted text will be saved to

extracted_text.txt

in the current directory.

Step 2: Analyze the Text

You must analyze the input text to extract information and evaluate it against the criteria defined in

references/nos_criteria.md

.

1. Extract Metadata:

• Study: First Author, Year (e.g., "Wang, 2018").

2. Evaluate Selection (4 items):

• D1: Representativeness of the Exposed Cohort (* or -)
  • Look for: study design (retrospective/prospective), data source (hospital registry/population-based), inclusion/exclusion criteria clarity
  • Give star if: representative sample from a defined population with clear criteria
• D2: Selection of the Non-Exposed Cohort (* or -)
  • Look for: comparison group source (same community/hospital/different source)
  • Give star if: drawn from the same source as exposed cohort
• D3: Ascertainment of Exposure (* or -)
  • Look for: how exposure was determined (medical records/interview/self-report)
  • Give star if: secure record (surgical records, pharmacy records, EMR) or structured interview
• D4: Outcome not present at start (* or -)
  • Look for: exclusion of patients with outcome at baseline
  • Give star if: demonstrated that outcome was not present at study start

3. Evaluate Comparability (2 items):

• D5: Age comparability (* or -)
  • Look for: age matching or statistical adjustment for age
  • Give star if: matched in design OR adjusted in analysis (not just "no difference" statement)
• D6: Additional comparability (* or -)
  • Look for: matching/adjustment for other key confounders (BMI, disease severity, comorbidities)
  • Give star if: matched in design OR adjusted in analysis for important factors beyond age

4. Evaluate Outcome (3 items):

• D7: Assessment of Outcome (* or -)
  • Look for: outcome measurement method (blind assessment/secure records/self-report)
  • Give star if: independent blind assessment, secure records (lab results, imaging), or record linkage
• D8: Enough follow-up (* or -)
  • Look for: duration of follow-up
  • Give star if: follow-up long enough for outcomes to occur (depends on disease/condition)
• D9: Adequacy of follow up (* or -)
  • Look for: follow-up completion rate, description of losses
  • Give star if: complete follow-up OR ≥80% follow-up with description of losses
  • Important: If follow-up rate not reported or <80%, do NOT give star

For each item, determine if it meets the criteria for a star (*). If not, or if uncertain, mark as (-).

Step 3: Format Data

Construct a JSON object with the results:

{
  "Study": "Wang, 2018",
  "D1": "*",
  "D2": "-",
  "D3": "*",
  "D4": "*",
  "D5": "*",
  "D6": "-",
  "D7": "*",
  "D8": "*",
  "D9": "-"
}

Scoring Notes:

• Be conservative: If uncertain about meeting criteria, use "-"
• For D9 (follow-up adequacy): Common issue is lack of reported completion rate
• Document your reasoning for each item

Step 4: Calculate Score and Generate Report

Run the python script to generate the final table:

python scripts/calculate_nos_score.py '<json_string>'

Example:

python scripts/calculate_nos_score.py "{\"Study\": \"Wei et al., 2026\", \"D1\": \"*\", \"D2\": \"*\", \"D3\": \"*\", \"D4\": \"*\", \"D5\": \"*\", \"D6\": \"*\", \"D7\": \"*\", \"D8\": \"*\", \"D9\": \"-\"}"

Important: JSON string must be properly escaped when passed via command line.

Step 5: Generate Final Report

Return to user:

1. The generated Markdown table
2. Brief explanation of each scoring decision
3. Summary of study quality (High: ≥7 stars, Moderate: 4-6 stars, Low: <4 stars)
4. Key strengths and limitations

Helper Scripts

PDF Text Extraction

When the user provides a PDF file path, use

scripts/extract_pdf.py

to extract the text content before assessment:

Features:

• Extracts text from all pages
• Saves output to

  extracted_text.txt

• Handles path issues with spaces
• Provides progress feedback

Usage:

python scripts/extract_pdf.py "path/to/file.pdf"

Output:

• Console: Extraction progress and statistics
• File:

  extracted_text.txt

  in current working directory

Quality Interpretation

Score	Quality Level	Recommendation
9 stars	Excellent	Low risk of bias, high confidence
7-8 stars	High quality	Acceptable for meta-analysis
4-6 stars	Moderate quality	Consider in sensitivity analyses
<4 stars	Low quality	High risk of bias, use caution

Common Issues and Solutions

1. PDF extraction fails: Check if file exists and is not corrupted; try different PDF library (PyMuPDF)
2. JSON parsing error: Ensure proper escaping of quotes in command line
3. Uncertain criteria: When in doubt, be conservative and assign "-"
4. Missing information: Note in report that certain items could not be assessed

References

• Detailed criteria:

  references/nos_criteria.md

• Wells GA, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses

When Not to Use

• Do not use this skill when the required source data, identifiers, files, or credentials are missing.
• Do not use this skill when the user asks for fabricated results, unsupported claims, or out-of-scope conclusions.
• Do not use this skill when a simpler direct answer is more appropriate than the documented workflow.

Required Inputs

• A clearly specified task goal aligned with the documented scope.
• All required files, identifiers, parameters, or environment variables before execution.
• Any domain constraints, formatting requirements, and expected output destination if applicable.

Output Contract

• Return a structured deliverable that is directly usable without reformatting.
• If a file is produced, prefer a deterministic output name such as

  cohort_study_quality_assessment_nos_result.md

  unless the skill documentation defines a better convention.
• Include a short validation summary describing what was checked, what assumptions were made, and any remaining limitations.

Validation and Safety Rules

• Validate required inputs before execution and stop early when mandatory fields or files are missing.
• Do not fabricate measurements, references, findings, or conclusions that are not supported by the provided source material.
• Emit a clear warning when credentials, privacy constraints, safety boundaries, or unsupported requests affect the result.
• Keep the output safe, reproducible, and within the documented scope at all times.

Failure Handling

• If validation fails, explain the exact missing field, file, or parameter and show the minimum fix required.
• If an external dependency or script fails, surface the command path, likely cause, and the next recovery step.
• If partial output is returned, label it clearly and identify which checks could not be completed.

Quick Validation

Run this minimal verification path before full execution when possible:

python scripts/calculate_nos_score.py --help

Expected output format:

Result file: cohort_study_quality_assessment_nos_result.md
Validation summary: PASS/FAIL with brief notes
Assumptions: explicit list if any