Source: https://github.com/aipoch/medical-research-skills

Meta Protocol Writer

This skill helps users generate a standard protocol for PROSPERO registration (without the registration number) for a Meta-analysis or Systematic Review.

When to Use

• Use this skill when you need generates a prospero-compliant meta-analysis protocol based on title and picos. use when the user wants to write a protocol for a systematic review or meta-analysis in a reproducible workflow.
• Use this skill when a protocol design task needs a packaged method instead of ad-hoc freeform output.
• Use this skill when the user expects a concrete deliverable, validation step, or file-based result.
• Use this skill when

  scripts/utils.py

  is the most direct path to complete the request.
• Use this skill when you need the

  meta-protocol-writer

  package behavior rather than a generic answer.

Key Features

• Scope-focused workflow aligned to: Generates a PROSPERO-compliant Meta-analysis protocol based on Title and PICOS. Use when the user wants to write a protocol for a systematic review or meta-analysis.
• Packaged executable path(s):

  scripts/utils.py

  .
• Reference material available in

  references/

  for task-specific guidance.
• Structured execution path designed to keep outputs consistent and reviewable.

Dependencies

• Python

  :

  3.10+

  . Repository baseline for current packaged skills.

• Third-party packages

  :

  not explicitly version-pinned in this skill package

  . Add pinned versions if this skill needs stricter environment control.

Example Usage

cd "20260316/scientific-skills/Protocol Design/meta-protocol-writer"
python -m py_compile scripts/utils.py
python scripts/utils.py --help

Example run plan:

1. Confirm the user input, output path, and any required config values.
2. Edit the in-file

   CONFIG

   block or documented parameters if the script uses fixed settings.
3. Run

   python scripts/utils.py

   with the validated inputs.
4. Review the generated output and return the final artifact with any assumptions called out.

Implementation Details

See

## Workflow

above for related details.

• Execution model: validate the request, choose the packaged workflow, and produce a bounded deliverable.
• Input controls: confirm the source files, scope limits, output format, and acceptance criteria before running any script.
• Primary implementation surface:

  scripts/utils.py

  .
• Reference guidance:

  references/

  contains supporting rules, prompts, or checklists.
• Parameters to clarify first: input path, output path, scope filters, thresholds, and any domain-specific constraints.
• Output discipline: keep results reproducible, identify assumptions explicitly, and avoid undocumented side effects.

Workflow

Follow these steps to generate the protocol.

1. Validate Title

Check if the user provided a title.

• If Title is missing: Ask the user to provide a title or suggest one based on PICOS if provided.
• If Title is present: Validate it using the Title Review Rules (see below).

Title Review Rules:

• Must contain "Meta-analysis" or "Systematic review".
• Must cover PICOS elements (Population, Intervention, Comparison, Outcome).
• Must be concise (< 25 words).

If the title fails validation, explain why and ask for a revised title.

2. Gather Inputs

Ensure you have the following information (PICOS):

• Participants (P)
• Interventions (I)
• Comparisons (C)
• Outcomes (O)

If any are missing, ask the user.

3. Generate Protocol Sections

Use the prompts in

references/prompts.md

to generate the three main sections. You must follow the content requirements and word counts strictly.

Step 3.1: Administrative Information

• Use the Administrative Information Prompt in

  references/prompts.md

  .
• Inputs: Validated Title, Author information (if known, else use placeholders).

Step 3.2: Introduction

• Use the Introduction Prompt in

  references/prompts.md

  .
• Inputs: PICOS.
• Constraints: Rationale (5-150 words), Objectives (10-200 words).

Step 3.3: Methods

• Use the Methods Prompt in

  references/prompts.md

  .
• Inputs: PICOS.
• Critical: For the Search Strategy, use the Current Date as the end date.
  • You can run

    python scripts/utils.py

    to get the exact current date if needed, or just use today's date known to you.
  • Start date must be "inception". Do NOT set a specific start year (e.g., 2000) unless requested.

4. Final Output

Combine the sections into a single Markdown document.

Structure:

1. Administrative Information
2. Introduction
3. Methods

Ensure all headings match the PROSPERO requirements.