OpenEvidence Rate Limits

Overview

OpenEvidence's clinical decision support API enforces strict rate limits to ensure reliable evidence retrieval for healthcare applications. Clinical query endpoints are throttled per API key, with lower limits on evidence synthesis calls that involve AI-powered literature analysis. In clinical settings, rate limiting directly impacts patient care workflows, so implementations must prioritize graceful degradation over retry storms. Batch research queries during off-peak hours and cache evidence summaries aggressively since medical literature changes infrequently.

Rate Limit Reference

Endpoint	Limit	Window	Scope
Clinical query	30 req	1 minute	Per API key
Evidence synthesis	10 req	1 minute	Per API key
Literature search	60 req	1 minute	Per API key
Citation retrieval	120 req	1 minute	Per API key
Bulk evidence export	5 req	1 hour	Per API key

Rate Limiter Implementation

class OpenEvidenceRateLimiter {
  private tokens: number;
  private lastRefill: number;
  private readonly max: number;
  private readonly refillRate: number;
  private queue: Array<{ resolve: () => void }> = [];

  constructor(maxPerMinute: number) {
    this.max = maxPerMinute;
    this.tokens = maxPerMinute;
    this.lastRefill = Date.now();
    this.refillRate = maxPerMinute / 60_000;
  }

  async acquire(): Promise<void> {
    this.refill();
    if (this.tokens >= 1) { this.tokens -= 1; return; }
    return new Promise(resolve => this.queue.push({ resolve }));
  }

  private refill() {
    const now = Date.now();
    this.tokens = Math.min(this.max, this.tokens + (now - this.lastRefill) * this.refillRate);
    this.lastRefill = now;
    while (this.tokens >= 1 && this.queue.length) {
      this.tokens -= 1;
      this.queue.shift()!.resolve();
    }
  }
}

const queryLimiter = new OpenEvidenceRateLimiter(25);
const synthesisLimiter = new OpenEvidenceRateLimiter(8);

Retry Strategy

async function openEvidenceRetry<T>(
  limiter: OpenEvidenceRateLimiter, fn: () => Promise<Response>, maxRetries = 3
): Promise<T> {
  for (let attempt = 0; attempt <= maxRetries; attempt++) {
    await limiter.acquire();
    const res = await fn();
    if (res.ok) return res.json();
    if (res.status === 429) {
      const retryAfter = parseInt(res.headers.get("Retry-After") || "30", 10);
      const jitter = Math.random() * 2000;
      await new Promise(r => setTimeout(r, retryAfter * 1000 + jitter));
      continue;
    }
    if (res.status >= 500 && attempt < maxRetries) {
      await new Promise(r => setTimeout(r, Math.pow(2, attempt) * 3000));
      continue;
    }
    throw new Error(`OpenEvidence API ${res.status}: ${await res.text()}`);
  }
  throw new Error("Max retries exceeded");
}

Batch Processing

async function batchClinicalQueries(queries: string[], batchSize = 5) {
  const results: any[] = [];
  for (let i = 0; i < queries.length; i += batchSize) {
    const batch = queries.slice(i, i + batchSize);
    const batchResults = await Promise.all(
      batch.map(q => openEvidenceRetry(queryLimiter, () =>
        fetch(`${OE_BASE}/api/v1/clinical/query`, {
          method: "POST", headers,
          body: JSON.stringify({ question: q, includeEvidence: true }),
        })
      ))
    );
    results.push(...batchResults);
    if (i + batchSize < queries.length) await new Promise(r => setTimeout(r, 12_000));
  }
  return results;
}

Error Handling

Issue	Cause	Fix
429 on clinical query	Exceeded 30 req/min query cap	Queue queries, return cached if available
429 on synthesis	Synthesis limit (10/min) is strict	Pre-cache common drug interaction queries
Synthesis timeout	Complex multi-study analysis	Set 120s timeout, poll async endpoint
401 key expired	API key rotation missed	Automate key rotation with 7-day buffer
Stale evidence	Cached result older than 30 days	Set TTL on cache, re-query on expiry

Resources

• OpenEvidence Platform

Next Steps

See

openevidence-performance-tuning

.